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KMID : 0366220120470030225
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Korean Journal of Hematology
2012 Volume.47 No. 3 p.225 ~ p.228
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A case of therapy-related acute myeloid leukemia with inv(16)(p13.1q22) after single low-dose iodine-131 treatment for thyroid cancer
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Jeong Ji-Hun
Ahn Jeong-Yeal
Park Soon-Ho
Park Mi-Jung
Kim Kyung-Hee
Hong Jun-Shik
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Abstract
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Radioiodine is regularly used in the treatment of thyroid cancer to eliminate residual malignant tissue after thyroidectomy and to treat metastasis. Because of the low dose of radioiodine used to treat thyroid cancer patients, leukemia is an uncommon complication of exposure to radioiodine. Here, we present a patient who developed therapy-related acute myeloid leukemia with inv(16)(p13.1q22);CBFb-MYH11, eosinophilia, and K-ras mutation and who had been treated with very low-dose radioiodine following total thyroidectomy.
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KEYWORD
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Radioiodine, Thyroid cancer, Acute myeloid leukemia, CBFb-MYH11, Eosinophilia, K-ras
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